1. The Hinterlands fits right into all types of games. It doesn't make the game SIGNIFICANTLY harder. Just something players have to keep an eye on. 2. Supercrisis cards: Oh dear. You want a challenge? Supercrisis makes Pandemic MUCH harder. You MUST put all 10 cards in if you're using them. If you use them, you MUST use Quarantines. I estimate they make the game 2 Epidemic cards harder. 3. Superbug: Even more, oh fuck. The game is impossible without the Superbug Medic, and even then, the game is t-o-u-g-h. I estimate it's 3 Epidemic cards harder with the Superbug. If you thought Pandemic should have Robinson Crusoe level of toughness, here it is. You can make it Ghost Stories difficult if you use In the Lab or Special Epidemics with either, or Supercrisis + Superbug.