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I am coming at this from a perspective of Alzheimer's and depression, and have been studying the viral hypothesis on neurological diseases. Minocycline, an old line antibiotic, has been shown in studies to be effective for treatment resistant depression and also Alzhiemer's in studies. It's safe, well tolerated, and crosses the BBB. You might consider that, given the success that it seems to be having as an antibiotic.
John, The best way is to find out what the infecting agent is by doing the provocative antibiotics test outlined here under latest developments. Then Pick the specific antibiotic for the bacteria involved. When an inflammatory process is present the BBB is no longer a barrier. Dr.T.
FYI .. https://www.mdedge.com/neurologyreviews/article/103463/multiple-sclerosis/minocycline-ms A simple search will turn up numerous studies and articles concerning minocycline an MS, as well as other studies for treatment resistant depression, Alzheimer's, etc. I don't know if minocycline is the only antibiotic that works but it has a good safety profile, a very long history, and is easily attainable and affordable. What antibiotics do you use in your treatments?
John, my daughter tested positive for Borrelia and we used Rocephin combined with Tinidazole to open up the cysts that protect the Borrelia. Her infection was in 2004 and untreated except for the DP until 2015 b/c we did not know her ALS was caused by Borrelia. If one treats a tick bite early with Doxycycline [a tetracycline as is minocycline] the Borrelia is killed. It is the late stages of infection , Chronic Lyme disease or neurodegenerative diseases , that the Borrelia are resistant to the Tetracyclines, hence combo antibiotics are used. There can also be co-infections that complicate the issue. Read the information on the web site. Dr.T.
Thanks, I will do so. Just curious .. how long was your daughter treated with Rocephin? Most of these studies I have read have really long term treatment periods (12 weeks and up to continual dosing). I have also read that some researchers have found that the benefit may be not just from the antibiotic nature of treatment but also from a leftover protein from the treatment. Again, since my focus is primarily on AD, most of what I have studied has been related to that. I used to discount the viral/bacterial infection hypothesis but with study after study, over a period of almost a decade, showing some positive benefit I am becoming inclined to consider this as a prime target in many neurological issues, including depressions. Just look at the explosion of the number of suicides in the medical community, which are often exposed to viruses in particular. Also depression in the general population. Humanity has a neurological crisis.
Between 2015 and 2018 there were complicating circumstances but she was treated with antibiotics the pulsed method for 8 months. The problem is neuroscientists refuse to accept the information documenting the infectious basis for all ND and much money is wasted on research in the wrong direction. WFND wants to fund more research but funds are limited. Google Dr's Alan Macdonald and Judith Miklossy on AD Dr.T.